The Effects of Stone Fruit Extract on the Process of Platelet Aggregation in Vitro
نویسندگان
چکیده
The Effects of Stone Fruit Extract on the Process of Platelet Aggregation in Vitro. (July 2011) Peter M. deLeeuw Department of Biomedical Sciences Texas A&M University Research Advisor: Dr. Luis Cisneros-Zevallos Department of Horticulture This project attempts to examine the impact stone fruits can have on the clotting of blood in the human body. Plum rich anthocyanin extract (RAE) was added in different concentrations (1-25μg/ml) to rabbit platelets suspended in Tyrode’s buffer and mixed in microplate wells. Platelet aggregation was then induced by 5 μM ADP (Adenosine Diphosphate), and the percent of transmittance was measured by a microplate reader. A change in aggregation of over 10% was recorded. The results suggest that the extract inhibits the aggregation caused by ADP. This would also lead one to believe that there are compounds in stone fruits that could lower the chances of cardiovascular disease by limiting aggregation and subsequently inflammation in arterial walls.
منابع مشابه
Evaluation of anti-platelet aggregation effect of some Allium species
Epidemiologic studies show that the cardiovascular diseases are associated with multiple factors such as raised serum total cholesterol, increased LDL, increased platelet aggregation, hypertension and smoking. In-vitro studies have confirmed the ability of some plants of Allium species to reduce these parameters. Therefore, we evaluated anti-platelet aggregation effect of some Allium species (A...
متن کاملEvaluation of anti-platelet aggregation effect of some Allium species
Epidemiologic studies show that the cardiovascular diseases are associated with multiple factors such as raised serum total cholesterol, increased LDL, increased platelet aggregation, hypertension and smoking. In-vitro studies have confirmed the ability of some plants of Allium species to reduce these parameters. Therefore, we evaluated anti-platelet aggregation effect of some Allium species (A...
متن کاملبررسی اثر عصاره هیدرو الکلی میوه گیاه سرو کوهی(Juniperus communis)بر انحلال سنگهای ادراری به سنگهای ادراری به صورت In vitro
Background and purpose:Urolithiasis is one of the most common diseases of urinary tract. Abdominal colicky pain, nausia, vomiting and hematuria are the major clinical findings. Treatments including oral drugs, lithitripsy, using ureteroscope and open surgery are expensive and may result in significant complications. The aim of this research was to find medications for dissolution of urinary sto...
متن کاملAcute nicotine treatment accelerates photochemically induced platelet aggregation in cerebral arterioles of mice: an in vivo study
When tobacco is smoked, chewed or snuffed, nicotine is absorbed by the lungs or mucous membrane and quickly moved into the bloodstream, where it is circulated throughout the brain. In fact nicotine is highly dangerous to be consumed in any form. The present study was conducted to know the adverse effects of nicotine on the platelet aggregation in cerebral microvessels of mice. Male mice of aver...
متن کاملSynergic effects of Summer Savory extract and aspirin on human platelets function
Introduction: Cardiovascular disease is one of the most common diseases in the world. In this account, atherosclerosis is one of the main cause’s heart attacks. Coagulation activity of platelets plays an important role in atherosclerotic plaque formation, thrombosis formation and cardiovascular diseases. Aspirin is the most commonly drugs which used as anti-platelet function to prevent and trea...
متن کامل